Analgesia in mice with experimental meningitis reduces pain without altering immune parameters

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Analgesia in mice with experimental meningitis reduces pain without altering immune parameters.

Intracranial lymphocytic choriomeningitis virus (LCMV) infection is a widely used animal model to study virus-induced cytotoxic T cell (CTL) mediated meningitis and immunopathology. Nevertheless, this model causes severe pain and distress in mice, especially at later stages of the disease. Therefore, new treatment regimens to improve animal welfare have to be developed. In this study, we subcut...

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0747-5632/$ see front matter 2011 Elsevier Ltd. A doi:10.1016/j.chb.2011.06.006 ⇑ Corresponding author. Address: Marquette Unive ogy, P.O. Box 1881, Milwaukee, WI 53201, United S (Office); fax: +1 414 288 5333. E-mail address: [email protected] (N.S 1 Present address: University of Oregon, Oregon, WA 2 Present address: BAE Systems, Analysis and Decisi ton, MA, United States. 3 Present ...

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ژورنال

عنوان ژورنال: ALTEX

سال: 2015

ISSN: 1868-596X

DOI: 10.14573/altex.1502021